Bioinformatics Protein Protein Interactions Online Exam Quiz
Bioinformatics Protein Protein Interactions GK Quiz. Question and Answers related to Bioinformatics Protein Protein Interactions. MCQ (Multiple Choice Questions with answers about Bioinformatics Protein Protein Interactions
Sets of proteins that are part of stable complexes and sets of proteins involved in transient interactions ____ in terms of the similarity in gene expression among the set of proteins.
Options
A : are similar
B : differ
C : are same
D : show similar function
Which of the following is incorrect about Purification of protein complexes followed by mass spectrometry?
Options
A : Isolating protein complexes from cells allows identification of interactions between ensembles of proteins instead of just pairs
B : Systematic purification of complexes on a large scale is done by tagging hundreds of genes with an epitope
C : UnLike in the yeast-two-hybrid assay, this does not involve chimeric genes
D : Affinity purification based on the epitope will then extract all the proteins attached to the bait protein from cell lysates
Correlation of gene expression for pairs of transiently interacting proteins is ______ compared to randomly chosen pairs of proteins.
Options
A : not significant
B : only marginally significant
C : totally significant
D : significant to much extent
There exist three types of interactions between domains. Which of the following is not one of them?
Options
A : Stable complex
B : Transient interaction
C : Multi-domain protein
D : Unstable interaction
Stable complexes consist of proteins that are _____ associated with each other, like many ____ proteins for instance.
Options
A : temporarily, oligomeric
B : temporarily, monomeric
C : permanently, oligomeric
D : permanently, monomeric
Which of the following is incorrect about Yeast-two-hybrid screens?
Options
A : The yeast-two-hybrid system uses the transcription of a reporter gene driven by the Gal4 transcription factor to monitor whether or not two proteins are interacting
B : The DNA-binding domain chimeric protein will not bind upstream of the reporter gene
C : If the activation domain chimeric protein interacts with the DNA-binding domain chimeric protein, the reporter gene will be transcribed
D : Disadvantages of the method are that only pairwise interactions are tested, and not interactions that can only take place when multiple proteins come together, as well as a high false positive rate
For proteins in stable complexes the average sequence identity is 46%, while for proteins in transient interactions it is 41%.
Options
A : True
B : False
C :
D :
Membership in a stable complex also differs from transient interaction in terms of evolutionary constraints upon sequence divergence.
Options
A : True
B : False
C :
D :
The physical contacts between domains are crucial for the functioning of the cellular machinery.
Options
A : True
B : False
C :
D :
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