Bioinformatics Protein Family Databases Online Exam Quiz
Bioinformatics Protein Family Databases GK Quiz. Question and Answers related to Bioinformatics Protein Family Databases. MCQ (Multiple Choice Questions with answers about Bioinformatics Protein Family Databases
Which of the following statements about CATH-Gene3D and HAMAP databases is incorrect regarding its features?
Options
A : CATH-Gene3D describes protein families and domain architectures in complete genomes
B : In CATH-Gene3D the functional annotation is provided to proteins from single resource
C : HAMAP profiles are manually created by expert curators they identify proteins that are part of well-conserved bacterial, archaeal and plastid-encoded proteins families or subfamilies.
D : HAMAP stands for High-quality Automated and Manual Annotation of microbial Proteomes
Which of the following statements about COG is incorrect regarding its features?
Options
A : Currently, there are 4,873 clusters in the COG databases derived from unicellular organisms
B : It is constructed by comparing protein sequences encoded in forty-three completely sequenced genomes, which are mainly from prokaryotes, representing thirty major phylogenetic lineages
C : The interface for sequence searching in the COG database is the COGnitor program, which is based on gapped BLAST
D : It is a protein family database based on structural classification
Which of the following statements about PRINTS and ProDom databases is incorrect regarding its features?
Options
A : PRINTS is a compendium of protein fingerprints
B : Usually the motifs do not overlap, but are separated along a sequence, though they may be contiguous in 3D-space
C : Current versions of ProDom are built using a novel procedure based on recursive BLAST searches
D : ProDom domain database consists of an automatic compilation of homologous domains
Which of the following statements about InterPro is incorrect regarding its features?
Options
A : Protein relatedness is defined by the P-values from the BLAST alignments
B : The most closely related sequences are grouped into the lowest level clusters
C : More distant protein groups are merged into higher levels of clusters
D : The outcome of this cluster merging is a tree-like structure of functional categories
Which of the following statements about SCOP is incorrect regarding its features?
Options
A : Proteins with the same shapes but having little sequence or functional similarity are placed in different super families, and are assumed to have only a very distant common ancestor
B : Proteins having the same shape and some similarity of sequence and/or function are placed in ‘families’, and are assumed to have a closer common ancestor
C : SCOP was created in 1994 in the Centre of Protein Engineering and the University College London
D : It aims to determine the evolutionary relationship between proteins
Which of the following is not a member database of InterPro?
Options
A : SCOP
B : HAMAP
C : PANTHER
D : Pfam
Which of the following statements about SUPERFAMILY database is incorrect regarding its features?
Options
A : Sequences can be submitted raw or FASTA format
B : Sequences must be submitted in FASTA format only
C : It searches the database using a superfamily, family, or species name plus a sequence, SCOP, PDB or HMM ID’s
D : It has generated GO annotations for evolutionarily closed domains and distant domains
Which of the following statements about PANTHER and TIGRFAMs databases is incorrect regarding its features?
Options
A : TIGRFAMs provides a tool for identifying functionally related proteins based on sequence homology
B : TIGRFAMs is a collection of protein families, featuring curated multiple sequence alignments, hidden Markov models (HMMs) and annotation
C : Hidden Markov models (HMMs) are not used in PANTHER
D : PANTHER is a large collection of protein families that have been subdivided into functionally related subfamilies, using human expertise
Pfam is available at four locations around the world. Which of the following is not one of them?
Options
A : UK
B : Sweden
C : US
D : Japan
What is the source of protein structures in SCOP and CATH?
Options
A : Uniprot
B : Protein Data Bank
C : Ensemble
D : InterPro
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