Bioinformatics Global Gene Regulation Online Exam Quiz
Bioinformatics Global Gene Regulation GK Quiz. Question and Answers related to Bioinformatics Global Gene Regulation. MCQ (Multiple Choice Questions with answers about Bioinformatics Global Gene Regulation
Which of the given statements is incorrect about Microarray (or microchip) analysis?
Options
A : It is a new technology in which all of the genes of an organism are represented by oligonucleotide sequences spread out in an 80 x 80 array on microscope slides
B : The oligonucleotide sequences cannot be synthesized directly on the slide
C : The oligonucleotides are collectively hybridized to a labeled cDNA library prepared by reverse-transcribing mRNA from cells
D : The amount of label binding to each oligonucleotide spot reflects the amount of mRNA in the cell
Which of the given statements is incorrect about Microarray Analysis?
Options
A : It is designed to detect global changes in transcription in a genome
B : It provides information about the levels of protein products of the genes
C : The proteins are first separated in a column on the basis of size and then across a second dimension on a slab on the basis of charge
D : Labeled protein samples may also be extracted from treated cells and separated by two-dimensional gel electrophoresis
In cluster analysis of microarray data– A node is created between the _________ scoring pair, and the gene expressed profiles of these two genes are averaged and the joined elements are weighted by the _________ of elements they contain.
Options
A : lowest, frequency
B : average, sequence
C : lowest, number
D : highest, number
In cluster analysis of microarray data– For n genes, the process is repeated ________ times until a single element remains.
Options
A : n2
B : n
C : n-1
D : n-4
Which of the given statements is incorrect about global gene regulation?
Options
A : One way to obtain useful information about a genome is to determine which genes are induced or repressed in response to a phase of the cell cycle
B : Sets of a gene whose expression rises and falls under the same condition are likely to have a related function
C : Sets of a gene whose expression rises and falls under the same condition are likely to have dissimilar functions
D : Cell cycle is a developmental phase, or a response to the environment
In cluster analysis of microarray data– If Xi is the log odds value for gene X at time i, then for two genes X and Y and N observations, a similarity score is calculated. S(X,Y) is also known as the Pearson correlation coefficent. Xoffset and Yoffset can be the mean of the observations on X or Y, respectively, in which case is the standard deviation, or else Xoffset and Yoffset can be set to zero when a reference state is used. Which of the following best represents it?
Options
A : S(X,Y) = frac{1}{N-2}1N?2 ?i=1,N . (Xi – Xoffset) (Yi + Yoffset)/?xQY
B : S(X,Y) = frac{1}{N}1N ?i=1,N . (Xi – Xoffset) (Yi – Yoffset)/?xQY
C : S(X,Y) = frac{1}{N-1}1N?1 ?i=1,N . (Xi + Xoffset) (Yi + Yoffset)/?xQY
D : S(X,Y) = frac{1}{N}1N ?i=1,N+2 . (Xi + Xoffset) (Yi – Yoffset)/?xQY
In Self-organizing maps a choice is made of a number of clusters by which to organize the data.
Options
A : True
B : False
C :
D :
Once a set of genes that are co-regulated has been found, the promoter regions of these genes may be analyzed for conserved patterns that represent sites of interaction with specific transcription factors.
Options
A : True
B : False
C :
D :
SVMs (Support vector machines) are a binary classification method to discriminate one set of data points from another.
Options
A : True
B : False
C :
D :
The hierarchical clustering method generates a similarity score [S(X,Y)] for all gene combinations, places the scores in a matrix, joins those genes that have the highest score, and then continues to join progressively less similar pairs.
Options
A : True
B : False
C :
D :
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